Development and optimization of microemulsion formulation. In one app it is possible to see how the oil and water phases behave, as 2 phase or 3 phase systems. Transdermal and topical delivery of antiinflammatory. Fraction of a phase is determined by taking the length of the tie line to the phase boundary for the other phase, and dividing by the total length of tie line. A foodgrade microemulsion system was composed of grape seed oil, soya lecithin, ethanol, and water. Sans from tetradecyipyridinium bromide based microemuisions paul m. The effect of the mass ratio of ctab to butan1ol k m m 21 m 22 and the water content on the phase diagram, and on the microemulsion structure were discussed. Optimization of selfmicroemulsifying drug delivery system. The aim of this work was to develop an innovative microemulsion with gellike properties for the cutaneous delivery of imiquimod, an immunostimulant drug employed for the treatment of cutaneous infections and neoplastic conditions. To play with that variable you can set a negative hld first and take a look at the height of the vertex of that system as you increase the length of the surfactant. A pseudoternary phase diagram was built using a 11 tpgs d. Aqueous phase microemulsion phase type i type iii type ii. The microemulsion regions were determined using a pseudoternary phase diagram, composed of oil, surfactant, and cosurfactant, where each component was indicated at the apex of a triangle.
At 45% wtwt surfactant system, microemulsions containing various ratios of water. Recently,westudiedamixtureofananionic andanonionicsurfactant,atvaryingratiosbetweenthetwo,to produce such onephase channel 15. The phases include conventional emulsion, gel viscous and transparent translucent microemulsion. The solubility region in the top part of the diagram is the wo microemulsion base, to which oil may. The dispersed phase, lipophilic or hydrophilic ow or wo nanoemulsions can behaves as a potential reservoir of lipophillic or hydrophilic drugs respectively. Sans from tetradecyipyridinium bromide based microemuisions. Effect of shortchain alcohols as cosurfactants on pseudo. The effect of formulation variables on different physicochemical characteristics such as % transmittance, and droplet size was studied. Jun 01, 2011 figure 2 shows a pseudoternary phase diagram for mixtures of palm kernel oil esters, tween 80, and water at various component compositions. Sample preparation for a pseudoternary phase diagram at constant temperature the phase behavior of water, propanol, sucrose laurate, and allylbenzene mixture is described in pseudoternary phase diagrams in which the weight ratio of propanolsucrose laurate is. The size area of the microemulsion region of the phase diagram was found to be dependent on the type of surfactant used and the loading level of drug vitamin e. In two phase region draw the tie line or isotherm 3. The resulting pseudoternary phase diagram is shown in figure 1 along with its depiction as a plane in a tetrahedral quaternary phase diagram.
The determination of the phase diagram was performed in a thermostated. Jul 24, 2015 the use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. The influence of the drug on microemulsion area was observed. The feasibility of this novel microemulsion system for the delivery of phenolic acids was studied by applying it to spent coffee phenolic extracts. In this study we designed and evaluated novel microemulsion based gels with indomethacin and analyzed the factors affecting their mechanical characteristics and drug release. Pseudoternary phase diagram of microemulsion composed.
The pseudoternary phase diagram was constructed for each system by plotting concentration of oil, surfactant and cosurfactant, a proper region was selected for formulation of microemulsion system from constructed pseudoternary phase diagrams. The size area of the microemulsion region of the phase diagram was found to be. However, it constructs a microemulsion and lamellar phase in a phase diagram without cosurfactant only at a narrow range of composition. Pseudoternary phase diagrams of water, oil and s smix of. A cryogenicelectron microscopy study of the onephase. The same effect may be brought about by adding a cosurfactant14. A series of ternary systems consisting of three components lemon oil, tween 20 or 80 and water were prepared at different ratios via gentle agitation by the phase inversion composition method involving the spontaneous formation of microemulsion. Characterization of microemulsions prepared using isopropyl. Preparation and evaluation of tretinoin microemulsion based on. In this study, the effect of several shortchain alcohols on pseudo. To deliver 2,3,5,6tetramethylpyrazine tmp in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. They have concluded that the interaction between water and oil domains is an important parameter affecting the stability of microemulsions roux et al. Conductivity, viscosity, ultrasonic velocity, and compressibility studies find consistent results in. Thermodynamic stability studies the thermodynamic stability of gliclazide microemulsion was evaluated using following stress tests in series.
Pseudoternary phase diagrams were constructed and on the basis of microemulsion existence range, various formulations were developed using oleic acid, tween80, propylene glycol and distilled water as oil phase, surfactant, cosurfactant and aqueous phase, respectively. It is the boundary line around that single phase region. Conductivity, viscosity, ultrasonic velocity, and compressibility studies find. Phase diagrams of wo microemulsion stabilised by non. Microstructure, morphology, and ultrafast dynamics of a.
A pseudoternary phase diagram was constructed using water titration method. An edible microemulsion me composed of tween 80butyl lactateisopropyl myristate ipmwater has been formulated. The singlephase boundary line is found on any section that contains a singlephase region. Throughout the article, two distinct gels, made of two different microemulsion droplets r. Tretinoin, phase diagram, microemulsion, differential. The study of phase diagram was primarily used as the guideline on the microemulsion formation. In selfemulsification and precipitation assessment evaluation of the selfemulsifying properties of smedds. Finding the amounts of phases in a two phase region. The pseudoternary phase diagram of four component mixtures of oil ethyl oleate, surfactant tween 80, cosurfactant soluphor p and water was constructed by titration technique to obtain concentration ranges that can result in large existence with the nanoemulsion region at room temperature 11.
One of the domains of the phase diagram shows structures that are not unlike highinternal. Pseudo ternary phase diagram is constructed to obtain the appropriate components and their concentration ranges that can result in large existence area of microemulsion. Isopleth through hypothetical ternary phase diagram at a constant. The heavy water content is increased while the other components. However, we provide links to pdf files of all diagrams. Construction of pseudoternary phase diagram pseudo ternary phase diagram is a useful and important tool to study the phase behaviour of microemulsions. Pseudoternary phase diagrams were constructed to find out the zone of microemulsion at different ratios of cremophor rh 40 to transcutol p e.
Various pseudoternary phase diagrams consisting of different oil, surfactant and. Pseudoternary diagram of an oilinwater propofol microemulsion of propofol oil, purified poloxamer 188 nonionic surfactant, and sodium caprylate ionic cosurfactant. Standard phase diagrams are graphical representations of the equilibrium relationships between minerals or others phases. Microemulsion based hydrogel of mycophenolate mofetil for. For two component systems like water and phenol, which are partially miscible, the phase diagram gives the information. Mpde practical surfactants science prof steven abbott. Design and optimization of chlordiazepoxide solid self. The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were. The critical points between microemulsion region and other phase regions were determined when the appearance of the system changed from clear to turbid, and vice versa. Phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. Pseudoternary phase diagram of the system contains a large single isotropic region. Design and formulation of optimized microemulsions for.
Note that the lower ucst may lie below the freezing point of the mixture. It is the boundary line around that singlephase region. In this article, the liquid is labeled microemulsion and the cosurfactant serves a dual purpose as active at the interface, but also as the organic solvent. Effect of surfactant and surfactant blends on pseudoternary. A phase diagram approach to determine the composition of. Finally, the uniformity of microemulsions was improved by the liposofast which. Pseudoternary phase diagram of microemulsion composed openi. Pseudoternary phase diagrams were used for the selection of microemulsion area. Pseudoternary phase diagram construction and optimization quantitative ratio of components for oilinwater ow type mes was set referring to available scientific data 2, 5, 10. Transdermal and topical delivery of antiinflammatory agents. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity. All types of dispersions, including conventional waterinoil and oilinwater emulsions, waterinoil and oilinwater microemulsions, bicontinuous and transitional liquid crystalline structures with. C is the weight fraction of cosurfactant, while s represents the same measure of surfactant.
Preparation, optimization and characterization of microemulsions 167 5. Pope center for petroleum and geosystems engineering. The region denoted llc refers to an undelineated region containing sin gle phase llcs and two phase compositions containing llcs. Microemulsion formulation peptide drug pseudoternary phase diagram lauryl ether hydrophilic phase. Formulation and evaluation of selfemulsifying drug. The oil labrafill m1944 cs was tested with scos in various ratios like 1. The pseudoternary phase diagrams were constructed by drop wise addition of double distilled water to homogenous liquid mixture of oil, surfactant. Prapaporn boonme, duangkhae maneenuan and wibul wongpoowarak. Pdf the purpose of this study is to give an insight into the. These relationships are governed by the laws of thermodynamics. In this study, pseudoternary phase diagrams of water, poes and. The use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. The singlephase boundary line is found on any section that.
Transdermal and topical delivery of antiinflammatory agents current nanoscience, 2010, vol. Another important variable that influences the shape of the ternary phase diagram is the length of the surfactant tail l. Nov 21, 2014 phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. This app, based on unpublished work by acosta, was a groundbreaking development. Rjpt microemulsions for the topical administration of 5. Characterization of microemulsion structures in the. Microstructure, morphology, and ultrafast dynamics of a novel. As per phase rule equation, a one component system should have maximum two degrees of freedom. Microemulsion how to construct ternary phase diagram anyone provide step by step tutorial. The impact of the microemulsion composition on the extent of isotropic region was investigated with the use of pseudoternary phase diagrams. Formulation and evaluation of selfemulsifying drug delivery. The single phase boundary line is found on any section that contains a single phase region. An easy way to do this is to open the files using acrobat or its equivalent and then save them as eps files or in some other format that your graphics program can import.
Phase diagrams of wo microemulsion stabilised by nonionic. Pseudoternary phase diagrams and formulation of microemulsion of lornoxicam almond oil oil, tween 20 surfactant, dmso cosurfactant were used for formulation of microemulsion using water titration method. Microemulsion based formulation as drug delivery system. Physical stability of the formulations were checked by. Pdf study of pseudoternary phase diagram behaviour and the.
Preparation and characterization of dexamethasone microemulsion based on pseudoternary phase diagram. In this method, adding the oil, surfactant mixture to some of the aqueous phase in a. Ternary phase diagram for a ternary system chapter 10. Formulation and development of microemulsion and smedds.
Preparation, optimization and characterization of microemulsions microemulsions are isotropic systems, which are difficult to formulate than ordinary emulsions because their formulation is a highly specific process involving. Pdf construction of pseudoternary phase diagram and its. The pseudo ternary phase diagrams of the oilsurfactantcosurfactant. Pseudoternary phase diagrams were constructed using various combinations of ingredients i. A ternary phase diagram has the shape of a triangular prism with an equilateral triangle as a foundation which is used to describe a three component system. In this study, methyl salicylate was successfully used as oil phase in the phase behavior study. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. Standard phase diagrams show how phases or phase assemblages change as a function of temperature, pressure, phase composition, or combinations of these variables. The drug partitions between dispersed and continuous phase. To obtain concentration range of components for the existing boundary of microemulsion.
Gellike tpgsbased microemulsions for imiquimod dermal. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity, viscosity, differential scanning calorimetry dsc, cryofield emission scanning electron microscopy cryofesem and. Preparation of nano and microemulsions using phase. Based on the results of previous studies 27, 29, several vehicles were screened, including capryol 90 and capmul mcm as an oil. Design and formulation of optimized microemulsions for dermal. Pseudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant and cosurfactant for microemulsion formulation, and the effect of these additives on skin permeation of 5fluorouracil was evaluated using keshary chien diffusion cells mounted with 0. To differentiate within the twophase region and singlephase region in the ternary diagram. Functionality of jerusalem artichoke derived inulin in. Physical characterization and stability of a microemulsion for. Microemulsion phase behavior type i type iii type ii. Ternary phase diagrams give the precise and accurate data of the various composite component systems and are.
At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared. This article is from jundishapur journal of natural pharmaceutical products, volume 8. Microemulsion based formulation as drug delivery system for. Effect of drug on the phase diagram the effect of the drug on the phase diagram was studied using pseudoternary phase diagram. Pseudoternary phase diagram of oil, water and surfactant. The phase behavior of the system is also studied at low ph 2. Pdf palm oil esters are high molecular weight esters oil that has been newly synthesized by university putra malaysia researchers. They can be viewed, printed, or edited with adobe illustrator or corel draw. The influence of drug loading level on the phase diagram was also determined. The phenomenon of phase inversion from wo microemulsion to ow microemulsion was also investigated for the drug delivery system consisting of soybean oil 0% ww vitamin e loading. The pseudoternary phase diagram of methyl salicylate.
Indian journal of pharmaceutical education and research vol 51 issue 4s octdec suppl, 2017 s573. Characterization of microemulsion structures in the pseudoternary. Ternary phase diagrams institute for advanced study. The increased incidence of inflammatory diseases has. Formulation and development of microemulsion and smedds akshay r. To study the phase behavior of different formulation components, most critical step is construction of pseudoternary phase diagram. The results showed that the wo microemulsion were located mostly at the surfactant mixtures apex and protruding towards the wateroil axis. Lecithin is a natural amphiphilic molecule, the microemulsions of which are often employed as a transdermal delivery medium of drugs and cosmetics. Construction of pseudoternary phase diagram is an important tool for. The suitability of amounts of surfactant, cosurfactant, oily, and aqueous phases for formulation of oilinwater ow type mes was confirmed by initial. The ac binary phase diagram shows three critical points. Pdf preparation and characterization of dexamethasone. Construction of pseudoternary phase diagram is an important tool for screening of selfdispersible formulation components and to assess the effect of different component on invitro performance of. Solubility enhancement of nebivolol by micro emulsion technique.
Pseudoternary phase diagrams of a drug delivery system. Novel microemulsionbased gels for topical delivery of. Methyl salicylate is miscible with the tween 20ipa1. Preparation and characterization of dexamethasone microemulsion. Microemulsion based hydrogel of mycophenolate mofetil for the. The first and second corners represented 100% of oo and w, respectively while the third corner referred to 100% of a binary mixture of smo and psmo. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. Pdf identification of phases of various oil, surfactant. The solubility region in the top part of the diagram is the wo microemulsion base, to which oil may be added to form a wo microemulsion.
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